PSP is a rare degenerative neurological disorder characterized by loss of balance when walking, loss of control of voluntary eye movement and other voluntary muscle activity (akinesia), abnormal rigidity (spasticity), postural instability, speech difficulties (dysarthria), and problems related to swallowing and eating (dysphagia).

Affected individuals frequently experience personality changes and cognitive impairment. For example, the ability to recognize, judge, and perceive may be affected. The exact cause of progressive supranuclear palsy is unknown.

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